Nailfold Capillaroscopy

Nailfold Capillaroscopy

Nailfold capillaroscopy (NFC) is a non-invasive, safe imaging technique used to examine the microcirculation at the base of the fingernail. This sophisticated diagnostic tool provides direct visualization of the tiny blood vessels (capillaries) in the nailfold area, offering valuable insights into your vascular health and potential autoimmune conditions.

Clinical Significance

NFC plays a crucial role in rheumatological diagnosis and monitoring. It is essential for differentiating primary Raynaud's phenomenon (a benign condition) from secondary Raynaud's phenomenon (which may indicate an underlying connective tissue disease). The test is particularly valuable for identifying early signs of connective tissue diseases, especially systemic sclerosis (scleroderma), often before other symptoms become apparent.

Diagnostic Applications

The capillary patterns observed during NFC can reveal important information about various autoimmune and rheumatological conditions. Abnormal capillary patterns—including enlarged capillaries, capillary loss, hemorrhages, or architectural disorganization—may suggest the presence of systemic sclerosis, mixed connective tissue disease, dermatomyositis, or other autoimmune disorders. Early detection through NFC allows for timely intervention and treatment, potentially improving long-term outcomes.

The Advantage of NFC

Unlike blood tests or invasive procedures, nailfold capillaroscopy provides real-time, direct visualization of microvascular changes. This makes it an invaluable tool for early diagnosis, disease monitoring, and assessing treatment response. The test is completely painless, carries no risks, and can be repeated as needed to track disease progression or improvement over time.

  • A nailfold capillaroscopy is a non-invasive, painless test performed on the hands that allows us to look at the small blood vessels (capillaries) around the nail beds. The test will be performed by a rheumatologist with experience in undertaking NFC. The clinician will use a specialised microscope along with vegetable oil on your nails to acquire high resolution pictures of the nailfold capillaries.

  • The findings of NFC are included in the diagnostic criteria of some rheumatologic disorders. Your rheumatologist has identified certain clinical or blood test characteristics that raise concern for an autoimmune disorder. The NFC may aid in diagnosis of autoimmune conditions, monitor progression/response to treatment and help to guide further investigations/treatments.

  • Your rheumatologist will receive an in-depth report and analysis of the test findings that will help them make future decisions about your care.

  • We ask that you avoid wearing any nail polish or other hand or nail accessories on the day of the test. We also suggest avoiding any activity that may cause trauma to your hands in the days leading up to the test. Arrive for your appointment at least 15 minutes early so your hands have time to acclimatise to room temperature.

  • The test will last approximately 15 minutes and will be undertaken at the Arthritis and Rheumatology Centre in Wantirna (161 Stud Road, Wantirna South).

Arthritis and Rheumatology Centre Melbourne